Publications
2024
Maeda, T., Furusawa, C. Laboratory Evolution of Antimicrobial Resistance in Bacteria to Develop Rational Treatment Strategies. Antibiotics. 18;13(1):94. (2024) >>PubMed
Shimada, M., Kawase, Y., Sonoyama, K., Ogura, Y., Hayashi, T., Yokota A., Fukiya, S.*
Development of an improved colonization system for human-derived Bifidobacterium longum subsp. longum in conventional mice through the feeding of raffinose or 1-kestose. Biosci Microbiota Food Health. 43:110-119 (2024). https://pubmed.ncbi.nlm.nih.gov/38562544/
Shinmori, A., Guo, Z., Maeda, T., Fukiya, S., Wada, M., Yokota, A. Contributions of the anaplerotic reaction enzymes pyruvate carboxylase and phosphoenolpyruvate carboxylase to l-lysine production in Corynebacterium glutamicum, J. Biosci. Bioeng. in press. (2024)
https://www.sciencedirect.com/science/article/pii/S1389172324001634?via%3Dihub
2023
Gowda, S.G.B, Hou, F., Gowda, D., Chiba, H., Kawakami, K., Fukiya, S., Yokota, A., Hui, S.P. *
Synthesis and quantification of short-chain fatty acid esters of hydroxy fatty acids in rat intestinal contents and fecal samples by LC-MS/MS. Anal Chim Acta. 1288:342145 (2023). https://pubmed.ncbi.nlm.nih.gov/38220280/
Hisatomi, A., Kastawa, N.W.E.P.G., Song, I., Ohkuma, M., Fukiya, S., Sakamoto, M.
Claveliimonas bilis gen. nov., sp. nov., deoxycholic acid-producing bacteria isolated from human faeces, and reclassification of Sellimonas monacensis Zenner et al. 2021 as Claveliimonas monacensis comb. nov. Int J Syst Evol Microbiol. 73:006030 (2023). doi:10.1099/ijsem.0.006030. PMID: 37737068. https://pubmed.ncbi.nlm.nih.gov/37737068/
Furusawa, C., Iwasawa, J., Maeda, T. Inference of Fitness Landscape Based on Multi-Dimensional Phenotype Measurements of Escherichia coli. Seibutsu Butsuri. 63(5) 263-265. (2023) >>J-STAGE
2022
Maeda, T., Furusawa, C. Laboratory Evolution of Antimicrobial Resistance in Bacteria to Develop Rational Treatment Strategies. Antibiotics. 19;13(1):94. (2024)
Maegawa, K., Koyama, H., Fukiya, S., Yokota, A., Ueda, K., and Ishizuka, S. Dietary raffinose ameliorates hepatic lipid accumulation induced by cholic acid via modulation of enterohepatic bile acid circulation in rats. British Journal of Nutrition, 127, 1621-1630 (2022). https://pubmed.ncbi.nlm.nih.gov/34256877/
Kawai, R., Toya, Y., Miyoshi, K., Murakami, M., Niide, T., Horinouchi, T., Maeda, T., Shibai, A., Furusawa, C., Shimizu, H. Acceleration of target production in co-culture by enhancing intermediate consumption through adaptive laboratory evolution. Biotechnol. Bioeng. 119. 936-945 (2022). >>PubMed
Kranz, A.,* Polen T., Kotulla, C., Arndt, A., Bosco, G., Bussmann, M., Chattopadhyay, A., Cramer, A., Davoudi, CF., Degner, U., Diesveld, R., von Boeselager, RF., Gärtner, K., Gätgens, C., Georgi, T., Geraths, C., Haas, S., Heyer, A., Hünnefeld, M., Ishige,T., Kabus, A., Kallscheuer, N., Kever, L., Klaffl, S., Kleine, B., Kočan, M., Koch-Koerfges, A., Kraxner, KJ., Krug, A., Krüger, A., Küberl, A., Labib, M., Lange, C., Mack, C., Maeda, T., Mahr, R., Majda, S., Michel, A., Morosov, X., Müller, O., Nanda, AM., Nickel, J., Pahlke, J., Pfeifer, E., Platzen, L., Ramp, P., Rittmann, D., Schaffer, S., Scheele, S., Spelberg, S., Schulte, J., Schweitzer, JE., Sindelar, G., Sorger-Herrmann, U., Spelberg, M., Stansen, C., Tharmasothirajan, A., van Ooyen, J., van Summeren-Wesenhagen, O., Vogt, M., Witthoff, S., Zhu, L., Eikmanns, BJ., Oldiges, M., Schaumann, G., Baumgart, M., Brocker, M., Eggeling, L., Freudl, R., Frunzke, J., Marienhagen, J., Wendisch, VF., Bott, M.* A manually curated compendium of expression profiles for the microbial cell factory Corynebacterium glutamicum. Sci. Data., 9, 594. (2022). >>PubMed
Iwasawa, J., Maeda, T., Shibai, A., Kotani, H., Kawada, M., Furusawa, C*. Analysis of the evolution of resistance to multiple antibiotics enables prediction of the Escherichia coli phenotype-based fitness landscape. PLoS Biol. 20. e3001920. (2022). >>PubMed
Hirasawa, T.,* Maeda, T. Adaptive Laboratory Evolution of Microorganisms: Methodology and Application for Bioproduction. Microorganisms. 11:92. (2022). >>PubMed
2021
Song, I., Gotoh, Y., Ogura, Y., Hayashi, T., Fukiya, S.*, and Yokota, A. Comparative genomic and physiological analysis against Clostridium scindens reveals Eubacterium sp. c-25 as an atypical deoxycholic acid producer of the human gut microbiota. Microorganisms, 9, 2254 (2021). https://pubmed.ncbi.nlm.nih.gov/34835380/
Hori, S., Satake, M., Kohmoto, O., Takagi, R., Okada, K., Fukiya, S., Yokota, A., and Ishizuka, S. * Primary 12α-hydroxylated bile acids lower hepatic iron concentration in rats. Journal of Nutrition, 151, 523-530 (2021). https://pubmed.ncbi.nlm.nih.gov/33438034/
Wada, M.,* Fukiya, S., Suzuki, A., Matsumoto, N., Matsuo, M., and Yokota, A. Methionine utilization by bifidobacteria: possible existence of a reverse transsulfuration pathway. Bioscience, Microbiota, Food and Health, 40, 80-83 (2021). https://pubmed.ncbi.nlm.nih.gov/33520573/
Hirano, R., Sakanaka, M., Yoshimi, K., Sugimoto, N., Eguchi, S., Yamauchi, Y., Nara, M., Maeda, S., Ami, Y., Gotoh, A., Katayama, T., Iida, N., Kato, T., Ohno, H., Fukiya, S., Yokota, A., Nishimoto, M., Kitaoka, M., Nakai, H.*, and Kurihara, S.* Next-generation prebiotic promotes selective growth of bifidobacteria, suppressing Clostridioides difficile. 13, 1973835 (2021). https://pubmed.ncbi.nlm.nih.gov/34553672/
Maeda, T. &, Koch-Koerfges, A. &, and Bott, M.* Relevance of NADH dehydrogenase and alternative two-enzyme systems for growth of Corynebacterium glutamicum with glucose, lactate, and acetate. Frontiers in Bioengineering and Biotechnology 8, DOI: 10.3389/fbioe.2020.621213 (2021). >>PubMed
Maeda, T.*, Shibai, A., Yokoi, N., Tarusawa, Y., Kawada, M., Kotani, H., Furusawa, C. Mutational property of newly identified mutagen L-glutamic acid γ-hydrazide in Escherichia coli. Mutat. Res., 823, 111759 (2021). >>PubMed
Maeda, T.*, Kawada, M., Sakata, N., Kotani, H., Furusawa, C. Laboratory evolution of Mycobacterium on agar plates for analysis of resistance acquisition and drug sensitivity profiles. Sci. Rep., 11, 15136 (2021). >>PubMed
Maeda, T.*, Kotani, H., Furusawa, C. Morphological change of coiled bacterium Spirosoma linguale with acquisition of β-lactam resistance. Sci. Rep., 11. 13278 (2021). >>PubMed
2020
Wada M, Fukiya S, Suzuki A, Matsumoto N, Matsuo M, and Atsushi Yokota. Methionine utilization by bifidobacteria: Possible existence of a reverse transsulfuration pathway. Biosci Microbiota Food Health, in press (2020) >>PubMed
Lee JY, Shimizu H, Hagio M, Fukiya S, Watanabe M, Tanaka Y, Joe GH, Iwaya H,Yoshitsugu R, Kikuchi K, Tsuji M, Baba N, Nose T, Tada K, Hanai T, Hori S, Takeuchi A, Furukawa Y, Shirouchi B, Sato M, Ooka T, Ogura Y, Hayashi T, Yokota A, Ishizuka S. 12α-hydroxylated bile acid induces hepatic steatosis with dysbiosis in rats.
Biochim Biophys Acta Mol Cell Biol Lipids.2020 Dec:158811 >>PubMed
Hori S, Abe T, Lee DG, Fukiya S, Yokota A, Aso N, Shirouchi B, Sato M,Ishizuka S. Association between 12α-hydroxylated bile acids and hepatic steatosis in rats fed a high-fat diet.
J Nutr Biochem. 2020 Sep;83:108412 >>PubMed
Gowda SGB, Liang C, Gowda D, Hou F, Kawakami K, Fukiya S, Yokota A, Chiba H, Hui SP. Identification of short chain fatty acid esters of hydroxy fatty acids (SFAHFAs) in murine model by nontargeted analysis using ultra-high-performance liquid chromatography/linear trap quadrupole-Orbitrap mass spectrometry.
Rapid Commun Mass Spectrom. 2020 Sep;15 >>PubMed
Koguchi H, Ishigami N, Sakanaka M, Yoshida K, Hiratou S, Shimada M, Fukiya S, Sonoyama K, Yokota A. Application of recombinase-based in vivo expression technology to Bifidobacterium longum subsp. longum for Identification of genes induced in the gastrointestinal tract of mice.
Microorganisms. 2020 Mar 13;8(3):410 >>PubMed
Gowda SGB, Gao ZJ, Chen Z, Abe T, Hori S, Fukiya S, Ishizuka S, Yokota A, Chiba H, Hui SP. Untargeted lipidomic analysis of plasma from high fat diet-induced obese rats using UHPLC- linear trap quadrupole -Orbitrap MS.
Anal Sci. 2020 Jan;17 >>PubMed
Gowda, S.G.B., Gowda, D., Liang, C., Li, Y., Kawakami, K., Fukiya, S., Yokota, A., Chiba, H., and Hui, S.P. * Chemical Labeling assisted detection and identification of short chain fatty acid esters of hydroxy fatty acid in rat colon and cecum contents. Metabolites, 10, 398 (2020). https://pubmed.ncbi.nlm.nih.gov/33050007/
Yoshioka, H., Watanabe, M., Nanba, F., Suzuki, T., Fukiya, S., Yokota, A., and Toda, T. * Administration of cholic acid inhibits equol production from daidzein in mice. Journal of Nutritional Science and Vitaminology, 66, 571-576 (2020). https://pubmed.ncbi.nlm.nih.gov/33390399/
2019
Kato, S., Tobe, H., Matsubara, H., Sawada, M., Sasaki, Y., Fukiya, S., et al. The membrane phospholipid cardiolipin plays a pivotal role in bile acid adaptation by Lactobacillus gasseri JCM1131T.
Biochim Biophys Acta - Mol Cell Biol Lipids 1864: 403-412(2019) >>PubMed
Kataoka N, Vangnai AS, Pongtharangkul T, Yakushi T, Wada M, Yokota A, Matsushita K.Engineering of Corynebacterium glutamicum as a prototrophic pyruvate-producing strain: Characterization of a ramA-deficient mutant and its application for metabolic engineering.
Biosci Biotechnol Biochem. 2019 Feb;83(2):372-380 >>PubMed
Sakanaka M, Hansen ME, Gotoh A, Katoh T, Yoshida K, Odamaki T, Yachi H, Sugiyama Y, Kurihara S, Hirose J, Urashima T, Xiao JZ, Kitaoka M, Fukiya S, Yokota A, Lo Leggio L, Abou Hachem M, Katayama T. Evolutionary adaptation in fucosyllactose uptake systems supports bifidobacteria-infant symbiosis.
Sci Adv. 2019 Aug 28;5(8):eaaw7696 >>PubMed
Lee DG, Hori S, Kohmoto O, Kitta S, Yoshida R, Tanaka Y, Shimizu H, Takahashi K, Nagura T, Uchino H, Fukiya S, Yokota A, Ishizuka S. Ingestion of difructose anhydride III partially suppresses the deconjugation and 7α-dehydroxylation of bile acids in rats fed with a cholic acid-supplemented diet.
Biosci Biotechnol Biochem. 2019 Jul;83(7):1329-1335 >>PubMed
2018
Sakanaka, M., Nakakawaji, S., Nakajima, S., Fukiya, S., Abe, A., Saburi, W., et al. A Transposon Mutagenesis System for Bifidobacterium longum subsp. longum based on an IS3 family insertion sequence, IS
Blo11. Appl Environ Microbiol 84: e00824-18(2018) >>PubMed
Shiraishi, T., Yokota, S., Sato, Y., Ito, T., Fukiya, S., Yamamoto, S., et al. Lipoteichoic acids are embedded in cell walls during logarithmic phase, but exposed on membrane vesicles in Lactobacillus gasseri JCM 1131T.
Benef Microbes 9: 653-662(2018) >>PubMed
2017
Tawthep S, Fukiya S, Lee JY, Hagio M, Ogura Y, Hayashi T, Yokota A. Isolation of six novel 7-oxo- or urso-type secondary bile acid-producing bacteria from rat cecal contents. Journal of Bioscience and Bioengineering in press (2017) doi: 10.1016/j.jbiosc.2017.06.002. >>PubMed
Watanabe M, Fukiya S, Yokota A. Comprehensive evaluation of the bactericidal activities of free bile acids in the large intestine of humans and rodents. Journal of LIPID RESEARCH. 58: 1143-1152(2017) doi: 10.1194/jlr.M075143 >>PubMed
Nagano S, Shibano K, Matsumoto Y, Yokota A, Wada M. Isolation and amino acid sequence of a dehydratase acting on D-erythro-3-hydroxyaspartate from Pseudomonas sp. N99, and its application in the production of optically active 3-hydroxyaspartate. Bioscience, Biotechnology, and Biochemistry. 81(6): 1156-1164 (2017) doi:10.1080/09168451.2017.1295804 >>Taylor Francis Online
Yokota A, Sawada K, Wada M. Boosting Anaplerotic Reactions by Pyruvate Kinase Gene Deletion and Phosphoenolpyruvate Carboxylase Desensitization for Glutamic Acid and Lysine Production in Corynebacterium glutamicum. Advances in Biochemical Engineering/Biotechnology. 159: 181-198 (2017) doi:10.1007/10_2016_31 >>PubMed
Maeda, S., Shimizu, K., Kihira, C., Iwabu, Y., Kato, R., Sugimoto, M., et al. Pyruvate dehydrogenase complex regulator (PdhR) gene deletion boosts glucose metabolism in Escherichia coli under oxygen-limited culture conditions. J Biosci Bioeng 123: 437-443(2017) >>PubMed
Nishiyama, K., Yamamoto, Y., Sugiyama, M., Takaki, T., Urashima, T., Fukiya, S., et al. Bifidobacterium bifidum extracellular sialidase enhances adhesion to the mucosal surface and supports carbohydrate assimilation. MBio 8: e00928-17(2017) >>PubMed
2016
Maeda S, Shimizu K, Kihira C, Iwabu Y, Kato R, Sugimoto M, Fukiya S, Wada M, Yokota A. Pyruvate dehydrogenase complex regulator (PdhR) gene deletion boosts glucose metabolism in Escherichia coli under oxygen-limited culture conditions. Journal of Bioscience and Bioengineering. 123(4):437-443 (2016) doi:10.1016/j.jbiosc.2016.11.004 >>PubMed
Yanase M, Aikoh T, Sawada K, Ogura K, Hagiwara T, Imai K, Wada M, Yokota A. Pyruvate kinase deletion as an effective phenotype to enhance lysine production in Corynebacterium glutamicum ATCC13032: Redirecting the carbon flow to a precursor metabolite. Journal of Bioscience and Bioengineering. 122 (2):160-167 (2016) doi:10.1016/j.jbiosc.2015.12.023 >>ScienceDirect
2015
Sawada K, Wada M, Hagiwara T, Zen-in S, Imai K, Yokota A. Effect of pyruvate kinase gene deletion on the physiology of Corynebacterium glutamicum ATCC13032 under biotin-sufficient non-glutamate-producing conditions: Enhanced biomass production.
Metabolic Engineering Communications.2:67-75.(2015) doi:10.1016/j.meteno.2015.07.001>>ScienceDirect
Wada M, Sawada K, Ogura K, Shimono Y, Hagiwara T, Sugimoto M, Onuki A, Yokota A. Effects of phosphoenolpyruvate carboxylase desensitization on glutamic acid production in Corynebacterium glutamicum ATCC 13032.
J Biosci Bioeng.15:S1389-1723.(2015) doi: 10.1016/j.jbiosc.2015.06.008. >>PubMed
Shimizu H, Baba N, Nose T, Taguchi R, Tanaka S, Joe GH, Maseda H, Nomura N, Hagio M, Lee JY, Fukiya S, Yokota A, Ishizuka S, Miyazaki H. Activity of ERK regulates mucin 3 expression and is involved in undifferentiated Caco-2 cell death induced by 3-oxo-C12-homoserine lactone.
Biosci Biotechnol Biochem. 79:937-42.(2015) doi: 10.1080/09168451.2015.1006570.>>PubMed
Sakanaka M, Fukiya S, Kobayashi R, Abe A, Hirayama Y, Kano Y, Yokota A. Isolation and transposition properties of ISBlo11, an active insertion sequence belonging to the IS3 family, from Bifidobacterium longum 105-A.
FEMS Microbiol Lett. 362 (2015) doi: 10.1093/femsle/fnv032. >>PubMed
Matsumoto Y, Yasutake Y, Takeda Y, Tamura T, Yokota A, Wada M. Structural insights into the substrate stereospecificity of D-threo-3-hydroxyaspartate dehydratase from Delftia sp. HT23: a useful enzyme for the synthesis of optically pure L-threo- and D-erythro-3-hydroxyaspartate.
Appl Microbiol Biotechnol. 99 (17):7137-50 (2015) doi: 10.1007/s00253-015-6479-3 >>PubMed
2014
Soma Y, Tsuruno K, Wada M, Yokota A, Hanai T. Metabolic flux redirection from a central metabolic pathway toward a synthetic pathway using a metabolic toggle switch.
Metabolic Engineering 23 :175-184 (2014) doi: 10.1016/j.ymben.2014.02.008. >>PubMed
Kanesaki Y, Masutani H, Sakanaka M, Shiwa Y, Fujisawa T, Nakamura Y, Yokota A, Fukiya S, Suzuki T, Yoshikawa H. Complete Genome Sequence of Bifidobacterium longum 105-A, a Strain with High Transformation Efficiency.
Genome Announc. 18 :01311-14 (2014) doi: 10.1128/genomeA.01311-14. >>PubMed
Hagio M, Shimizu H, Joe GH, Takatsuki M, Shiwaku M, Xu H, Lee JY, Fujii N, Fukiya S, Hara H, Yokota A, Ishizuka S. Diet supplementation with cholic acid promotes intestinal epithelial proliferation in rats exposed to γ-radiation.
Toxicol Lett. 232:246-252 (2014) doi: 10.1016/j.toxlet.2014.10.011. >>PubMed
Sakanaka M, Tamai S, Hirayama Y, Onodera A, Koguchi H, Kano Y, Yokota A, Fukiya S. Functional analysis of bifidobacterial promoters in Bifidobacterium longum and Escherichia coli using the α-galactosidase gene as a reporter.
J Biosci Bioeng. 118:489-95 (2014) doi: 10.1016/j.jbiosc.2014.05.002. >>PubMed
Shimizu H, Hagio M, Iwaya H, Tsuneki I, Lee JY, Fukiya S, Yokota A, Miyazaki H, Hara H, Ishizuka S. Deoxycholic acid is involved in the proliferation and migration of vascular smooth muscle cells.
J Nutr Sci Vitaminol. 60 :450-4 (2014) doi: 10.3177/jnsv.60.450. >>PubMed
2013
Matsumoto Y, Yasutake Y, Takeda Y, Tamura T, Yokota A, Wada M. Crystallization and preliminary X-ray diffraction studies of D-threo-3-hydroxyaspartate dehydratase isolated from Delftia sp. HT23
Acta Crystallogr. Sect. F, 69:1131-1134 (2013) >>PubMed
Lee JY, Arai H, Nakamura Y, Fukiya S, Wada M, Yokota A. Contribution of the 7β-hydroxysteroid dehydrogenase from Ruminococcus gnavus N53 to ursodeoxycholic acid formation in the human colon.
J Lipid Res.(2013). >>PubMed
Sakurama H, Kiyohara M, Wada J, Honda Y, Yamaguchi M, Fukiya S, Yokota A, Ashida H, Kumagai H, Kitaoka M, Yamamoto K, Katayama T. Lacto-N-biosidase Encoded by a Novel Gene of Bifidobacterium longum Subspecies longum Shows Unique Substrate Specificity and Requires a Designated Chaperone for Its Active Expression.
J Biol Chem., 288:25194-25206 (2013) >>PubMed
Shiraishi T, Yokota S, Morita N, Fukiya S, Tomita S, Tanaka N, Okada S, Yokota A. Characterization of a Lactobacillus gasseri JCM 1131T lipoteichoic acid with a novel glycolipid anchor structure.
Appl Environ Microbiol., 79:3315-3318 (2013) >>PubMed
2012
Fukiya S, Hirayama Y, Sakanaka M, KANO Y, Yokota A. Technological Advances in Bifidobacterial Molecular Genetics: Application to Functional Genomics and Medical Treatments
Bioscience of Microbiota, Food and Health, 31:15-25 (2012) >>J-STAGE
Kihira C, Hayashi Y, Azuma N, Noda S, Maeda S, Fukiya S, Wada M, Matsushita K, Yokota A. Alterations of glucose metabolism in Escherichia coli mutants defective in respiratory-chain enzymes.
J Biotechnol, 158:215-223 (2012) >>PubMed
Hirayama Y, Sakanaka M, Fukuma H, Murayama H, Kano Y, Fukiya S, Yokota A. Development of a Double-Crossover Markerless Gene Deletion System in Bifidobacterium longum: Functional Analysis of the α-Galactosidase Gene for Raffinose Assimilation.
Appl Environ Microbiol, 78:4984-4994(2012). >>PubMed
Sawada K, Kato Y, Imai K, Li L, Wada M, Matsushita K, Yokota A. Mechanism of increased respiration in an H+-ATPase-defective mutant of Corynebacterium glutamicum.
J Biosci Bioeng, 113:467-473(2012). >>PubMed
Yokota A, Fukiya S, Ooka T, Ogura Y, Hayashi T, Ishizuka S. Is bile acid a determinant of the gut microbiota on a high-fat diet?
Gut Microbes, 3:epub ahead of print(2012). >>PubMed
2011
Islam KB, Fukiya S, Hagio M, Fujii N, Ishizuka S, Ooka T, Ogura Y, Hayashi T, Yokota A. Bile acid is a host factor that regulates the composition of the cecal microbiota in rats.
Gastroenterology, 141:1773–1781(2011). >>PubMed
Kihira C, Hayashi Y, Azuma N, Noda S, Maeda S, Fukiya S, Wada M, Matsushita K, Yokota A. Alterations of glucose metabolism in Escherichia coli mutants defective in respiratory-chain enzymes.
Journal of Biotechnology, 158:215-223(2011). >>PubMed
2010
Kikuchi H, Sakurai H, Nagura T, Aritsuka T, Tomita F, Yokota A. One-pot conversion of levan prepared from Serratia levanicum NN to difructose anhydride IV by Arthrobacter nicotinovorans levan fructotransferase.
Journal of Bioscience and Bioengineering, 109: 240-243 (2010). >>PubMed
Sawada K, Zen-in S, Wada M, Yokota A. Metabolic changes in a pyruvate kinase gene deletion mutant of Corynebacterium glutamicum ATCC 13032.
Metabolic Engineering, 12: 401-407 (2010). >>PubMed
Fukiya S, Sugiyama T, Kano Y, Yokota A. Characterization of an insertion sequence-like element ISBlo15 identified in a size-increased cryptic plasmid pBK283 harbored in Bifidobacterium longum BK28.
Journal of Bioscience and Bioengineering, 110: 141-146 (2010). >>PubMed
Suzuki T, Nishimukai M, Shinoki A, Taguchi H, Fukiya S, Yokota A, Saburi W, Yamamoto T, Hara H, Matsui H. Ingestion of epilactose, a non-digestible disaccharide, improves postgastrectomy osteopenia and anemia in rats through the promotion of intestinal calcium and iron absorption.
Journal of Agricultural and food chemistry, 58: 10787-10792 (2010). >>PubMed
Maeda T, Takeda Y, Murakami T, Yokota A, Wada M. Purification, characterization and amino acid sequence of a novel enzyme, D-threo-3-hydroxyaspartate dehydratase, from Delftia sp. HT23.
Journal of Biochemistry, 148: 705-712 (2010). >>Oxford Academic
2009
Hiroto Kikuchi, Masanao Inoue, Hidetoshi Saito, Hiroaki Sakurai, Tsutomu Aritsuka, Fusao Tomita, and Atsushi Yokota. Industrial production of difructose anhydride III (DFA III) from crude inulin extracted from chicory roots using Arthrobacter sp. H65-7 fructosyltransferase.
Journal of Bioscience and Bioengineering, 107: 262-265 (2009). >>PubMed
Senoura T, Taguchi H, Ito S, Hamada S, Matsui H, Fukiya S, Yokota A, Watanabe J, Wasaki J, Ito S. Identification of the Cellobiose 2-Epimerase Gene in the Genome of Bacteroides fragilis NCTC 9343.
Bioscience Biotechnology and Biochemistry, 73: 400-406 (2009). >>PubMed
Satoru Fukiya, Miki Arata, Hiroko Kawashima, Daisuke Yoshida, Maki Kaneko, Kimiko Minamida, Jun Watanabe, Yoshio Ogura, Kiyohisa Uchida, Kikuji Itoh, Masaru Wada, Susumu Ito and Atsushi Yokota. Conversion of cholic acid and chenodeoxycholic acid into their 7-oxo derivatives by Bacteroides intestinalis AM-1isolated from human feces.
FEMS Microbiology Letters, 293: 263-270 (2009). >>PubMed
Ogami, Shinichi, Hijikata, Shoichi, Tsukahara, Tamostu, Mie, Yasuhiro, Matsuno, Toshihide, Morita, Naoki, Hara, Isao, Yamazaki, Koji, Inoue, Norio, Yokota, Atsushi, Hoshino, Tamotsu, Yoshimune, Kazuaki, Yumoto, Isao. A membrane-anchored cytochrome c-550 of alkaliphilic Bacillus clarkii K24-1U: Expression, molecular features and properties of redox potential.
Extremophiles, 13(3):491-504 (2009) >>PubMed
Murakami T, Maeda T, Yokota A, Wada M. Gene cloning and expression of pyridoxal 5'-phosphate-dependent L-threo-3-hydroxyaspartate dehydratase from Pseudomonas sp. T62, and characterization of the recombinant enzyme.
Journal of Biochemistry, 145(5):661-668 (2009) >>PubMed
Miki, S., Matsui, K., Kito, H., Otsuka, K., Ashizawa, T., Yasuda, N., Fukiya, S., Sato, J., Hirayae, K., Fujita, Y., Nakajima, T., Tomita, F., and Sone, T. Molecular cloning and characterization of the AVR-Pia locus from a Japanese field isolate of Magnaporthe oryzae.
Molecular Plant Pathology, 10(3): 361-374 (2009). >>PubMed
2008
M. Wada, K. Okabe, M. Kataoka, S. Shimizu, A. Yokota, H. Takagi, Distribution of L-azetidine-2-carboxylate N-acetyltransferese in yeast.
Bioscience Biotechnology and Biochemistry, 72: 582-586, (2008). >>PubMed
E. Yahata, Y. Sawatari, H. Sugiyama, A. Hanakoka, A. Yokota and H. Saruyama. Change of proteins in instant Chinese noodle by the fermentation of Lactobacillus plantarum NRIC0380 affects the noodle quality.
Food Science and Technology Research. 14: 285-292 (2008). >>J-STAGE
S. Ishizuka, A Iwama, A. Dinoto, A. Suksomcheep, K. Maeta, T. Kasai, H. Hara and A. Yokota. Synbiotic promotion of epithelial proliferation by orally ingested encapsulated Bifidobacterium breve and raffinose in the small intestine of rats.
Molecular Nutrition & Food Research. 2008 Oct 7. >>PubMed
M. Wada, N. Hijikata, R. Aoki, N. Takesue, A. Yokota. Enhanced valine production in Corynebacterium glutamicum with defective H+-ATPase and C-terminal truncated acetohydroxyacid synthase.
Bioscience Biotechnology and Biochemistry, 72: 2959-2965 (2008). >>PubMed
2007
M. Wada, K. Narita, A. Yokota, Alanine production in an H+-ATPase- and lactate dehydrogenase-defective mutant of Escherichia coli expressing alanine dehydrogenase.
Applied Microbiology and Biotechnology, 76: 819-825 (2007). >>PubMed
L. Li, M. Wada, A. Yokota, A comparative proteomic approach to understand the adaptations of an H+-ATPase-defective mutant of Corynebacterium glutamicum ATCC14067 to energy deficiencies.
Proteomics, 7: 3348-3357 (2007). >>PubMed
L. Li, M. Wada, and A. Yokota, Cytoplasmic proteome reference map for a glutamic acid-producing Corynebacterium glutamicum ATCC14067.
Proteomics, 7: 4317-4322 (2007). >>PubMed
M. P. Ongol, Y. Sawatari, Y. Ebina, T. Sone, M. Tanaka, F. Tomita, A. Yokota and K. Asano. Yoghurt fermented by Lactobacillus delbrueckii subsp. bulgaricus H+-ATPase-defective mutants exhibits enhanced viability of Bifidobacterium breve during storage.
International Journal of Food Microbiology, 116: 358-366 (2007). >>PubMed
Y. Sawatari and A.Yokota. Diversity and mechanisms of alkali tolerance in lactobacilli.
Applied and Environmental Microbiology, 73: 3909-3915 (2007). >>PubMed
2006
P. Kurdi, K. Kawanishi, K. Mizutani, and A. Yokota. Mechanism of growth inhibition by free bile acids in lactobacilli and bifidobacteria.
Journal of Bacteriology, 188: 1979-1986 (2006). >>PubMed
Sakiko Noda, Yuji Takezawa, Tomohiko Mizutani, Tomoaki Asakura, Eiichiro Nishiumi, Kazunori Onoe, Masaru Wada, Fusao Tomita, Kazunobu Matsushita and Atsushi Yokota. Alterations of cellular physiology in Escherichia coli in response to oxidative phosphorylation impaired by defective F1-ATPase.
Journal of Bacteriology, 188: 6869-6876 (2006). >>PubMed
Y. Haitani, N. Awano, M. Yamazaki, M. Wada, S. Nakamori, H. Takagi, Functional analysis of L-serine O-acetyltransferase from Corynebacterium glutamicum.
FEMS Microbiology Letters, 255: 156-163, (2006). >>PubMed
A. Dinoto, A. Suksomcheep, S. Ishizuka, H. Kimura, S. Hanada, Y. Kamagata, K. Asano, F. Tomita, and A. Yokota. Modulation of Rat Cecal Microbiota by the Administration of Raffinose and Encapsulated Bifidobacterium breve.
Applied and Environmental Microbiology, 72: 784-792 (2006). >>PubMed
A. Dinoto, T. M. Marques, K. Sakamoto, S. Fukiya, J. Watanabe, S. Ito and A. Yokota Population dynamics of Bifidobacterium species in human feces during raffinose administration monitored by FISH-flow cytometry.
Applied and Environmental Microbiology. 72: 7739-7747 (2006). >>PubMed
Y. Sawatari, T. Hirano, and A. Yokota. Development of food grade media for the preparation of Lactobacillus plantarum starter culture.
Journal of General and Applied Microbiology. 52: 349-356 (2006). >>PubMed
2005
Central metabolism: sugar uptake and conversion, In: L. Eggeling and M. Bott (eds.), Handbook of Corynebacterium glutamicum, CRC Press, pp.215-240 (2005).>>ResearchGate
N. Awano, M. Wada, H. Mori, S. Nakamori, H. Takagi, Identification and functional analysis of Escherichia coli cysteine desulfhydrases.
Applied and Environmental Microbiology, 71: 4149-4152 (2005). >>PubMed
C.-C. Hsu, Z. Hong, M. Wada, D. Franke, C.-H. Wong, Directed evolution of D-sialic acid aldolase to L-3-deoxy-manno-2-octulosonic acid (L-KDO) aldolase.
Proceedings of the National Academy of Sciences of the USA, 102: 9122-9126 (2005). >>PubMed
R. Aoki, M. Wada, N. Takesue, K. Tanaka and A. Yokota. Enhanced glutamic acid production by a H+-ATPase-defective mutant of Corynebacterium glutamicum.
Bioscience Biotechnology and Biochemistry, 69: 1466-1472 (2005).>>PubMed
Y. Sawatari, H. Sugiyama, Y. Suzuki, A. Hanaoka, K. Saito,H. Yamauchi, S. Okada and A. Yokota. Development of the fermented instant Chinese noodle using Lactobacillus plantarum.
Food Microbiology, 22: 539-546 (2005).>>PubMed
ASM. Selim, P. Boonkumklao, T. Sone, A. Assavanig, M. Wada and A. Yokota. Development and assessment of a Real-Time PCR assay for the rapid and sensitive detection of a novel thermotolerant bacterium, Lactobacillus thermotolerans, in chicken feces.
Applied and Environmental Microbiology, 71: 4214-4219 (2005). >>PubMed
2004
M. Kataoka, A. Kotaka, R. Thiwthong, M. Wada, S. Nakamori, S. Shimizu. Cloning and overexpression of the old yellow enzyme gene of Candida macedoniensis, and its application to the production of a chiral compound.
Journal of Biotechnology., 114: 1-9 (2004). >>PubMed
2003
N. Awano, M. Wada, A. Kohdoh, T. Oikawa, H. Takagi, S. Nakamori, Effect of cysteine desulfhydrase gene disruption on L-cysteine overproduction in Escherichia coli.
Applied Microbiology and Biotechnology, 62: 239-243 (2003). >>PubMed
S. Sogabe, A. Yoshizumi, T. A. Fukami, Y. Shiratori, S. Shimizu, H. Takagi, S. Nakamori, M. Wada, The crystal structure and stereospecificity of levodione reductase from Corynebacterium aquaticum M-13
Journal of Biological Chemistry, 278: 19387-19395 (2003). >>PubMed
P. Kurdi, H. Tanaka, H. W. van Veen, K. Asano, F. Tomita and A. Yokota.: Cholic acid accumulation and its diminution by short-chain fatty acids in bifidobacteria.
Microbiology, 149(8): 2031-2037 (2003). >>PubMed
Niamsup, P., Sujaya, I. N., Tanaka, M., Sone, T., Hanada, S., Kamagata, Y., Lumyong, S., Assavanig, A., Asano, K., Tomita, F., and Yokota, A.: Lactobacillus thermotolerans sp. nov., a novel thermotolerant species isolated from chiken faeces.
International Journal of Systematic and Evolutionary Microbiology, 53: 263-268 (2003). >>PubMed
K. Saito, Y. Oda, F. Tomita and A. Yokota. Molecular cloning of the gene for 2,6-beta-D-fructan 6-levanbiohydrolase from Streptomyces exfoliates F3-2.
FEMS Microbiology Letters, 218: 265-270 (2003). >>PubMed
K. Saito, Y. Sumita, Y. Nagasaka, F. Tomita and A. Yokota. Molecular cloning of the gene encoding the di-D-fructofuranose 1,2':2,3' dianhydride hydrolysis enzyme (DFA IIIase) from Arthrobacter sp. H65-7.
Journal of Bioscience and Bioengineering, 95: 538-540 (2003). >>PubMed
2002
M. Kataoka, A. Kotaka, A. Hasegawa, M. Wada, A. Yoshizumi, S. Nakamori, S. Shimizu. Old yellow enzyme from Candida macedoniensis catalyzes the stereospecific reduction of the C=C bond of ketoisophorone.
Bioscience Biotechnology and Biochemistry, 66: 2651-2657 (2002). >>PubMed