Tomoya Maeda
Assistant Professsor
前田 智也
学位
出身校
専門
農学部担当
農学院担当
研究テーマ
博士（工学）
東京工業大学生命理工学部生命工学科（和地研究室）
微生物生理学
生物機能化学科｜微生物生理学
農学専攻｜生命フロンティアコース｜応用生物化学ユニット
産業微生物の代謝制御機構の解明，及び発酵生産の効率化
細菌の薬剤耐性ダイナミクスの解明，及び耐性進化の予測と
制御法の開発
環境微生物の異種間相互作用による共生関係の解明
卒業後の略歴
2008.4-2009.9
Master's Program, Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
2009.10-2012.3
Doctoral Program, Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology (Ph.D. in Engineering, March 2012)
2012.4-6
Postdoctral researcher at Tokyo Institute of Technology, Department of Bioengineering
2012.7-2013.8
Forschungszentrum Juelich, Institute of Bio-and Geosciences IBG-1, Postdoctoral researcher
2013.9-2015.12
Researcher at Research Institute of Innovative Technology for the Earth, Molecular Microbiology and Biotechnology group
2016.1-2018.3
Postdoctral researcher at RIKEN, Quantitative Biology Center
2009.10-2010.3
Institute of Biochemistry, University of Cologne
research student
2018.4-2021.1
Special postdoctral researcher at RIKEN, Center for Biosystems Dynamics Research
2021.2-
Assistant Professor at Hokkaido University, Research Faculty of Agriculture
◆For more details→ researchmap
Featured Publications
◆Original Paper
1. Maeda, T., and Wachi, M.* 3' Untranslated region-dependent degradation of the aceA mRNA, encoding the glyoxylate cycle enzyme isocitrate lyase, by RNase E/G in Corynebacterium glutamicum. Applied and Environmental Microbiology 78, 8753-8761 (2012).
https://pubmed.ncbi.nlm.nih.gov/23042181/
2. Maeda, T., Tanaka, Y., Takemoto, N., Hamamoto, N., and Inui, M.* RNase III mediated cleavage of the coding region of mraZ mRNA is required for efficient cell division in Corynebacterium glutamicum. Molecular Microbiology 99, 1149-1166 (2016).
https://pubmed.ncbi.nlm.nih.gov/26713407/
3. Maeda, T., Tanaka, Y., and Wachi, M., and Inui, M.* Polynucleotide phosphorylase, RNase E/G, and YbeY are involved in the maturation of 4.5S RNA in Corynebacterium glutamicum. Journal of Bacteriology 199, e00798-00816. (2017).
https://pubmed.ncbi.nlm.nih.gov/28031281/
4. Maeda, T., Tanaka, Y., and Inui, M.* Glutamine-rich toxic proteins GrtA, GrtB, and GrtC together with the antisense RNA AsgR constitute a toxin-antitoxin-like system in Corynebacterium glutamicum. Molecular Microbiology 108, 578-594 (2018).
https://pubmed.ncbi.nlm.nih.gov/29537126/
5. Maeda, T.*, Takaaki, H., Sakata, N., Sakai, A., and Furusawa. C. High-throughput identification of the sensitivities of an Escherichia coli ∆recA mutant strain to various chemical compounds. The Journal of Antibiotics 72, 566-573 (2019).
https://pubmed.ncbi.nlm.nih.gov/30792518/
6. Maeda, T. * &, Iwasawa, J. &, Kotani, H., Sakata, N., Kawada, M., Horinouchi, T., Sakai, A., Tanabe, K., and Furusawa, C.* High-throughput laboratory evolution reveals evolutionary constraints in Escherichia coli. Nature Communications 11, 5970 (2021).
https://pubmed.ncbi.nlm.nih.gov/33235191/
7. Maeda, T. &, Koch-Koerfges, A. &, and Bott, M.* Relevance of NADH dehydrogenase and alternative two-enzyme systems for growth of Corynebacterium glutamicum with glucose, lactate, and acetate. Frontiers in Bioengineering and Biotechnology 8, DOI: 10.3389/fbioe.2020.621213 (2021).
https://pubmed.ncbi.nlm.nih.gov/33585420/
8. Maeda, T.*, Shibai, A., Yokoi, N., Tarusawa, Y., Kawada, M., Kotani, H., Furusawa, C. Mutational property of newly identified mutagen L-glutamic acid γ-hydrazide in Escherichia coli. Mutat. Res., 823, 111759 (2021).
https://pubmed.ncbi.nlm.nih.gov/34304126/
9. Maeda, T.*, Kawada, M., Sakata, N., Kotani, H., Furusawa, C. Laboratory evolution of Mycobacterium on agar plates for analysis of resistance acquisition and drug sensitivity profiles. Sci. Rep., 11, 15136 (2021).
https://pubmed.ncbi.nlm.nih.gov/34302035/
10. Maeda, T.*, Kotani, H., Furusawa, C. Morphological change of coiled bacterium Spirosoma linguale with acquisition of β-lactam resistance. Sci. Rep., 11. 13278 (2021).
https://pubmed.ncbi.nlm.nih.gov/34168257/
◆Review
1. 古澤力, 前田智也, 芝井厚 「腸内細菌叢生態学 大腸菌進化実験の表現型・遺伝子型解析 微生物生態系進化の予測と制御へ向けて」実験医学, 羊土社, 38号18 pp 3072-3077 (2020). >>羊土社
2. Furusawa C., Horinouchi, T., Maeda, T., Toward prediction and control of antibiotic-resistance evolution, Current Opinion in Biotechnology 54, 45-49 (2018). >>PubMed
3. Horinouchi, T., Maeda, T., and Furusawa, C., Understanding and engineering alcohol-tolerant bacteria using OMICS technology. World Journal of Microbiology and Biotechnology 34(11), 157. (2018). >>PubMed
4. 古澤力, 前田智也, 堀之内貴明 「ラボ内での全自動実験室進化システムの構築」 実験医学別冊 あなたのラボにAI（人工知能）×ロボットがやってくる 研究に生産性と創造性をもたらすテクノロジー」羊土社, pp 112-115 (2017). >>羊土社
5. 前田智也, 和地正明 解説「細菌におけるRNaseを介した代謝制御 産業微生物コリネ型細菌を例に」 化学と生物, 国際文献社, 53巻 P99-106 (2015). >>J-STAGE
6. Hirasawa, T.,* Maeda, T. Adaptive Laboratory Evolution of Microorganisms: Methodology and Application for Bioproduction. Microorganisms. 11:92. (2022).
https://pubmed.ncbi.nlm.nih.gov/36677384/
7. Maeda, T. *, Furusawa, C. Laboratory Evolution of Antimicrobial Resistance in Bacteria to Develop Rational Treatment Strategies. Antibiotics. 19;13(1):94. (2024)