Satoru Fukiya
Professor
吹谷 智

Degree |
Ph.D. (Agriculture)
Education |
Graduate School of Agriculture, Hokkaido University
(Department of Agricultural Chemistry)
Specialization |
Microbial Physiology, Applied Microbiology, Molecular Biology
Affiliation |
Professor, Faculty of Agriculture, Hokkaido University
Topics |
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Analysis of the Structure and Function of Gut Microbiot
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Development of a Genetic Manipulation System for Bifidobacteria and Gene Function Analysis
Career
1997
Master's Program in Agricultural Chemistry, Graduate School of Agriculture, Hokkaido University
1997
Doctoral Program in Agricultural Chemistry, Graduate School of Agriculture, Hokkaido University
2001-2003
Researcher, NEDO Project, Tokyo Research Institute, Kyowa Hakko Kogyo Co., Ltd.
2003-2004
Researcher, Basic Research Institute, Kitasato Institute
2004-2005
Researcher, Graduate School of Pharmaceutical Sciences, Chiba University
2005
Assistant, Graduate School of Agriculture, Hokkaido University
2006
Reassigned due to organizational restructuring: Assistant, Research Faculty of Agriculture, Hokkaido University
2007
Assistant Professor, Research Faculty of Agriculture, Hokkaido University
2013
Lecturer, Research Faculty of Agriculture, Hokkaido University
2021
Associate Professor, Research Faculty of Agriculture, Hokkaido University
2022
Professor, Research Faculty of Agriculture, Hokkaido University
◆For more details → researchmap
Featured Publications
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Fukiya, S., Arata, M., Kawashima, H., Yoshida, D., Kaneko, M., Minamida, K., Watanabe, J. Ogura, Y., Uchida, K., Itoh, K., Wada, M., Ito, S., and Yokota, A. Conversion of cholic acid and chenodeoxycholic acid into their 7-oxoderivatives by Bacteroides intestinalis AM-1isolated from human feces. FEMS Microbiology Letters, 293: 263-270 (2009). https://pubmed.ncbi.nlm.nih.gov/19243441/
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Islam, K.B.M.S., Fukiya, S., Hagio, M., Fujii, N., Ishizuka, S., Ooka, T., Ogura, Y., Hayashi, T., and Yokota, A. Bile acid is a host factor that regulates the composition of the cecal microbiota in rats. Gastroenterology, 141: 1773-1781 (2011). https://pubmed.ncbi.nlm.nih.gov/21839040/
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Hirayama, Y., Sakanaka, M., Fukuma, H., Murayama, H., Kano, Y., Fukiya, S.*, Yokota, A. Development of a double-crossover markerless gene deletion system in Bifidobacterium longum: functional analysis of the α-galactosidase gene for raffinose assimilation. Applied and Environmental Microbiology, 78: 4984-4994 (2012). https://pubmed.ncbi.nlm.nih.gov/22582061/
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Sakanaka, M., Fukiya, S.*, Kobayashi, R., Abe, A., Hirayama, Y., Kano, Y., and Yokota, A. Isolation and transposition properties of ISBlo11, an active insertion sequence belonging to the IS3 family, from Bifidobacterium longum 105-A. FEMS Microbiology Letters, 362: fnv032 (2015). https://pubmed.ncbi.nlm.nih.gov/25724534/
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Watanabe, M., Fukiya, S., and Yokota, A. Comprehensive evaluation of the bactericidal activities of free bile acids in the large intestine of humans and rodents. Journal of Lipid Research, 58, 1143-1152 (2017). https://pubmed.ncbi.nlm.nih.gov/28404640/
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Sakanaka, M., Nakakawaji, S., Nakajima, S., Fukiya, S.*, Abe, A., Saburi, W., Mori, H., and Yokota, A. A transposon mutagenesis system for Bifidobacterium longum subsp. longum based on an IS3 family insertion sequence, ISBlo11. Applied and Environmental Microbiology, 84: e00824-18 (2018). https://pubmed.ncbi.nlm.nih.gov/29934330/
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Koguchi, H., Ishigami, N., Sakanaka, M., Yoshida, K., Hiratou, S., Shimada, M., Fukiya, S.*, Sonoyama, K., and Yokota, A. Application of recombinase-based in vivo expression technology to Bifidobacterium longum subsp. longum for identification of genes induced in the gastrointestinal tract of mice. Microorganisms, 8:410 (2020). https://pubmed.ncbi.nlm.nih.gov/32183191/
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Lee, J.Y., Shimizu, H., Hagio, M., Fukiya, S., Watanabe, M., Tanaka, Y., Joe, G.H., Iwaya, H., Yoshitsugu, R., Kikuchi, K., Tsuji, M., Baba, N., Nose, T., Tada, K., Hanai, T., Hori, S., Takeuchi, A., Furukawa, Y., Shirouchi, B., Sato, M., Ooka, T., Ogura, Y., Hayashi, T., Yokota, A., and Ishizuka, S. 12α-hydroxylated bile acid induces hepatic steatosis with dysbiosis in rats. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1865:158811 (2020). https://pubmed.ncbi.nlm.nih.gov/32896622/
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Song, I., Gotoh, Y., Ogura, Y., Hayashi, T., Fukiya, S, *, and Yokota, A. Comparative genomic and physiological analysis against Clostridium scindens reveals Eubacterium sp. c-25 as an atypical deoxycholic acid producer of the human gut microbiota. Microorganisms, 9: 2254 (2021). https://pubmed.ncbi.nlm.nih.gov/34835380/
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Shimada, M., Kawase, Y., Sonoyama, K., Ogura, Y., Hayashi, T., Yokota A., Fukiya, S.* Development of an improved colonization system for human-derived Bifidobacterium longum subsp. longum in conventional mice through the feeding of raffinose or 1-kestose. Biosci Microbiota Food Health. 43:110-119 (2024). https://pubmed.ncbi.nlm.nih.gov/38562544/
■総説・解説等
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Yokota, A., Fukiya, S., Islam, K.B.M.S., Ooka, T., Ogura, Y., Hayashi, T., Ishizuka, S. Is bile acid a determinant of the gut microbiota on a high-fat diet? Gut Microbes, 3: 455-459 (2012). https://pubmed.ncbi.nlm.nih.gov/22825495/
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Fukiya, S., Hirayama, Y., Sakanaka, M., Kano, Y., and Yokota, A. Technological Advances in Bifidobacterial Molecular Genetics: Application to Functional Genomics and Medical Treatments. Bioscience of Microbiota, Food and Health, 31 (2): 15–25 (2012) https://pubmed.ncbi.nlm.nih.gov/24936345/
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吹谷 智.ビフィズス菌における実用的な遺伝子変異導入系の開発(2015年度 生物工学奨励賞(斎藤賞)受賞論文).日本生物工学会誌,94(3): 110-116 (2016) https://cir.nii.ac.jp/crid/1520853833456857856
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Shiraishi, T., Yokota, S., Fukiya, S. Yokota, A. Structural diversity and biological significance of lipoteichoic acid in Gram-positive bacteria: focusing on beneficial probiotic lactic acid bacteria. Biosci. Microbiota. Food. Health., 35(4): 147-161 (2016).
https://pubmed.ncbi.nlm.nih.gov/27867802/
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吹谷 智,横田 篤.腸内細菌の機能理解に向けて:ビフィズス菌における遺伝子操作系の開発.化学と生物,55(9): 637-643 (2017).
https://doi.org/10.1271/kagakutoseibutsu.55.637
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Dinoto, A., Fukiya, S., and Yokota, A. FISH-Flow Cytometry: A high-throughput molecular ecological analysis of intestinal microbiota. Japanese Journal of Lactic Acid Bacteria, 17(2): 110-117(2006).>> Web site
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吹谷 智,横田 篤: 新たな腸内細菌叢解析手法としてのFISH-フローサイトメトリー法. 生化学,80(5): 421-425 (2008).>> Web site
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吹谷 智,横田 篤: 急展開を見せる腸内細菌研究;大規模シークエンス解析により明らかになってきた腸内細菌叢の構造と機能. 化学と生物,74(1): 11-13 (2009).>> Web site